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Article

P2Y2 receptor polymorphisms and haplotypes in cystic fibrosis and their impact on Ca2+ influx.

Pharmacogenetics and genomics - 1 Mar 2006

Büscher Rainer, Hoerning André, Patel Hemal H, Zhang Shen, Arthur David B, Grasemann Hartmut, Ratjen Felix, Insel Paul A

Abstract excerpt

OBJECTIVE: Activation of P2Y2 receptors in airway epithelia by ATP and UTP stimulates a Ca2+-regulated Cl- channel, which regulates Cl- secretion in cystic fibrosis (CF). We hypothesized that genetic alterations in the P2Y2 receptor may act as disease modifiers in CF and thus analyzed the coding region of this gene for polymorphisms in 146 CF patients and 64 healthy controls. We also assessed the impact of the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 16495779
DOI: 10.1097/01.fpc.0000189798.11468.6a

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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