Article
CXCR1 and CXCR2 haplotypes synergistically modulate cystic fibrosis lung disease.
The European respiratory journal - 1 Jun 2012
Kormann Michael S D, Hector Andreas, Marcos Veronica, Mays Lauren E, Kappler Matthias, Illig Thomas, Klopp Norman, Zeilinger Sonja, Carevic Melanie, Rieber Nikolaus, Eickmeier Olaf, Zielen Stefan, Gaggar Amit, Moepps Barbara, Griese Matthias, Hartl Dominik
Abstract excerpt
Cystic fibrosis (CF) lung disease severity is largely independent on the CF transmembrane conductance regulator (CFTR) genotype, indicating the contribution of genetic modifiers. The chemokine receptors CXCR1 and CXCR2 have been found to play essential roles in the pathogenesis of CF lung disease. Here, we determine whether genetic variation of CXCR1 and CXCR2 influences CF lung disease severity. Genomic DNA of...
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