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Article

Variants in the glutamate-cysteine-ligase gene are associated with cystic fibrosis lung disease.

American journal of respiratory and critical care medicine - 15 Aug 2006

McKone Edward F, Shao Jing, Frangolias Daisy D, Keener Cassie L, Shephard Cynthia A, Farin Federico M, Tonelli Mark R, Pare Peter D, Sandford Andrew J, Aitken Moira L, Kavanagh Terrance J

Abstract excerpt

BACKGROUND: Chronic progressive lung disease is the most serious complication of cystic fibrosis (CF). Glutathione plays an important role in the protection of the CF lung against oxidant-induced lung injury. OBJECTIVES: We hypothesized that a polymorphism in a novel candidate gene that regulates glutathione synthesis might influence CF lung disease. METHODS: In a cross-sectional study, subjects were recruited...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 16690975
DOI: 10.1164/rccm.200508-1281OC
PMCID: PMC2648118

Genes

GCLC
CFTR
FEV

Provenance

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