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Article

Rpn4 is a physiological substrate of the Ubr2 ubiquitin ligase.

The Journal of biological chemistry - 31 Dec 2004

Wang Li, Mao Xicheng, Ju Donghong, Xie Youming

Abstract excerpt

The homeostatic abundance of the proteasome in Saccharomyces cerevisiae is controlled by a feedback circuit in which transcriptional activator Rpn4 up-regulates the proteasome genes and is destroyed by the assembled, active proteasome. Remarkably, the degradation of Rpn4 can be mediated by two independent pathways. One pathway is independent of ubiquitin, whereas the other involves ubiquitination on internal...

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Source

Identifiers

PMID: 15504724
DOI: 10.1074/jbc.M410085200

Genes

UBR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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Rpn4 is a physiological substrate of the Ubr2 ubiquitin ligase.PMID 15504724Read ↗

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