Article
A ubiquitin stress response induces altered proteasome composition.
Cell - 18 May 2007
Hanna John, Meides Alice, Zhang Dan Phoebe, Finley Daniel
Abstract excerpt
Ubiquitin-dependent protein degradation is essential for cells to survive many environmental stresses. Thus, it may be necessary to buffer ubiquitin and proteasome pools against fluctuation. Proteasome levels are tightly regulated, and proteasome deficiency stimulates a stress response. Here we report a novel pathway of cellular response to ubiquitin depletion. Unlike proteasome stress, ubiquitin stress does not...
Topics
- Endopeptidases
- Enzyme Activation
- Gene Expression Regulation, Fungal
- Mutation
- Proteasome Endopeptidase Complex
- Saccharomyces cerevisiae
- Saccharomyces cerevisiae Proteins
- Ubiquitin
- Up-Regulation