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Article

Proteasome subunit Rpn13 is a novel ubiquitin receptor.

Nature - 22 May 2008

Husnjak Koraljka, Elsasser Suzanne, Zhang Naixia, Chen Xiang, Randles Leah, Shi Yuan, Hofmann Kay, Walters Kylie J, Finley Daniel, Dikic Ivan

Abstract excerpt

Proteasomal receptors that recognize ubiquitin chains attached to substrates are key mediators of selective protein degradation in eukaryotes. Here we report the identification of a new ubiquitin receptor, Rpn13/ARM1, a known component of the proteasome. Rpn13 binds ubiquitin through a conserved amino-terminal region termed the pleckstrin-like receptor for ubiquitin (Pru) domain, which binds K48-linked...

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Identifiers

PMID: 18497817
DOI: 10.1038/nature06926
PMCID: PMC2839886

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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