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Article

Proteasome recruitment and activation of the Uch37 deubiquitinating enzyme by Adrm1.

Nature cell biology - 1 Sept 2006

Yao Tingting, Song Ling, Xu Wei, DeMartino George N, Florens Laurence, Swanson Selene K, Washburn Michael P, Conaway Ronald C, Conaway Joan Weliky, Cohen Robert E

Abstract excerpt

Uch37 is one of the three principal deubiquitinating enzymes (DUBs), and the only ubiquitin carboxy-terminal hydrolase (UCH)-family protease, that is associated with mammalian proteasomes. We show that Uch37 is responsible for the ubiquitin isopeptidase activity in the PA700 (19S) proteasome regulatory complex. PA700 isopeptidase disassembles Lys 48-linked polyubiquitin specifically from the distal end of the...

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PMID: 16906146
DOI: 10.1038/ncb1460

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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