Article
Homeostatic regulation of the proteasome via an Rpn4-dependent feedback circuit.
Biochemical and biophysical research communications - 13 Aug 2004
Ju Donghong, Wang Li, Mao Xicheng, Xie Youming
Abstract excerpt
The 26S proteasome is a complex protease consisting of at least 32 different subunits. Early studies showed that Rpn4 (also named Son1 and Ufd5) is a transcriptional activator of the Saccharomyces cerevisiae proteasome genes, and that Rpn4 is rapidly degraded by the 26S proteasome. These observations suggested that in vivo proteasome abundance may be regulated by an Rpn4-dependent feedback circuit. Here, we...
Topics
- DNA-Binding Proteins
- Feedback
- Genotype
- Kinetics
- Peptide Hydrolases
- Proteasome Endopeptidase Complex
- Protein Subunits
- Saccharomyces cerevisiae
- Saccharomyces cerevisiae Proteins
- Trans-Activators
- Transcription Factors