Article
Hyper IgE in New Zealand black mice due to a dominant-negative CD23 mutation.
Immunogenetics - 1 Nov 2004
Lewis Graham, Rapsomaniki Eleni, Bouriez Tiphaine, Crockford Tanya, Ferry Helen, Rigby Robert, Vyse Timothy, Lambe Teresa, Cornall Richard
Abstract excerpt
Immunoglobulin E (IgE) plays a critical role in both resistance to parasitic infection and allergy to environmental antigens. The IgE response is in turn regulated by the B-cell co-receptor CD23, and CD23-deficient mice show exaggerated IgE responses and airway hyper-responsiveness. In this report, we show that New Zealand black (NZB) mice express a variant CD23 allele, with mutations in both the C-lectin-binding...
Topics
- Alleles
- Amino Acid Sequence
- Animals
- Immunoglobulin E
- Job Syndrome
- Mice
- Mice, Inbred C57BL
- Mice, Inbred NZB
- Molecular Sequence Data
- Point Mutation
- Receptors, IgE