Article
Hyper IgE in New Zealand black mice due to a dominant-negative CD23 mutation.
Immunogenetics - 1 Nov 2004
Lewis Graham, Rapsomaniki Eleni, Bouriez Tiphaine, Crockford Tanya, Ferry Helen, Rigby Robert, Vyse Timothy, Lambe Teresa, Cornall Richard
Abstract excerpt
Immunoglobulin E (IgE) plays a critical role in both resistance to parasitic infection and allergy to environmental antigens. The IgE response is in turn regulated by the B-cell co-receptor CD23, and CD23-deficient mice show exaggerated IgE responses and airway hyper-responsiveness. In this report, we show that New Zealand black (NZB) mice express a variant CD23 allele, with mutations in both the C-lectin-binding...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.