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Article

CD23: an overlooked regulator of allergic disease.

Current allergy and asthma reports - 1 Sept 2007

Conrad Daniel H, Ford Jill W, Sturgill Jamie L, Gibb David R

Abstract excerpt

Given the importance of immunoglobulin (Ig) E in mediating type I hypersensitivity, inhibiting IgE production would be a general way of controlling allergic disease. The low-affinity IgE receptor (FceRII or CD23) has long been proposed to be a natural regulator of IgE synthesis. In vivo research supporting this concept includes the observation that mice lacking CD23 have increased IgE production whereas mice...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17697638
DOI: 10.1007/s11882-007-0050-y

Genes

ADAM10

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

CD23: an overlooked regulator of allergic disease.PMID 17697638Read ↗

Uncoupling of natural IgE production and CD23 surface expression levels.Semantic proximity Read ↗

Structural and Functional Insights Into IgE Receptor Interactions and Disruptive InhibitionSemantic proximity Read ↗

The absence of IgE antibody-mediated augmentation of immune responses in CD23-deficient mice.Semantic proximity Read ↗

The role of IgE, IgG, and IgA in tolerance, sensitization, and targeted treatment of allergic diseaseSemantic proximity Read ↗

Hyper IgE in New Zealand black mice due to a dominant-negative CD23 mutation.Semantic proximity Read ↗

Regulation of IgE homeostasis, and the identification of potential targets for therapeutic interventionSemantic proximity Read ↗

129/SvJ mice have mutated CD23 and hyper IgE.Semantic proximity Read ↗

A mite subversive: cleavage of CD23 and CD25 by Der p 1 enhances allergenicitySemantic proximity Read ↗

Humoral Response Suppression Observed with CD23 TransgenicsSemantic proximity Read ↗

Inhibition of immunoglobulin class-switching prevents pemphigus onset in desmoglein 3-specific B cell receptor knock-in mouseSemantic proximity Read ↗

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CD23 shedding: requirements for substrate recognition and inhibition by dipeptide hydroxamic acids.Semantic proximity Read ↗

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