Article
Mutation in Mpzl3, a novel [corrected] gene encoding a predicted [corrected] adhesion protein, in the rough coat (rc) mice with severe skin and hair abnormalities.
The Journal of investigative dermatology - 1 Jun 2007
Cao Tongyu, Racz Peter, Szauter Kornelia M, Groma Gergely, Nakamatsu Garrett Y, Fogelgren Benjamin, Pankotai Eszter, He Qing-Ping, Csiszar Katalin
Abstract excerpt
The rough coat (rc), an autosomal-recessive mutation, arose spontaneously in C57BL/6J mice. Homozygous rc mice develop severe skin and hair abnormalities, including cyclic and progressive hair loss and sebaceous gland hypertrophy. The rc locus was previously mapped to Chromosome 9. To elucidate the genetic basis underlying the rc phenotype development, we carried out positional cloning, and mapped the rc locus to...
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