Article
Targeted somatic mutagenesis in the mouse epidermis.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2005
Metzger Daniel, Li Mei, Chambon Pierre
Abstract excerpt
The efficient introduction of somatic mutations in a given gene at a given time and in specific cell types of the skin will greatly facilitate the studies of a number of genes expressed in the skin and the production of animal models for skin diseases. We describe here strategies and techniques to create spatiotemporally controlled somatic mutations of target genes in the skin using a conditional Cre/LoxP system....
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