Article
Skin abnormalities generated by temporally controlled RXRalpha mutations in mouse epidermis.
Nature - 5 Oct 2000
Li M, Indra A K, Warot X, Brocard J, Messaddeq N, Kato S, Metzger D, Chambon P
Abstract excerpt
Nuclear receptors for retinoids (RARs) and vitamin D (VDR), and for some other ligands (TRs, PPARs and LXRs), maybe critical in the development and homeostasis of mammalian epidermis. It is believed that these receptors form heterodimers with retinoid X receptors (RXRs) to act as transcriptional regulators. However, most genetic approaches aimed at establishing their physiological functions in the skin have been...
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