Article
An approach for controlling the timing and order of engineered mutations in mice.
Genesis (New York, N.Y. : 2000) - 1 Aug 2018
Goodrich Maxwell M, Talhouk Ramzi, Zhang Xiaojing, Goodrich David W
Abstract excerpt
Significant advances in our understanding of normal development and disease have been facilitated by engineered mice in which genes can be altered in a spatially, temporally, or cell type restricted manner using site specific recombinase systems like Cre-loxP or Flp-frt. In many circumstances it is important to understand how interactions between multiple genes influence a given phenotype. Robust approaches for...
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