Article
The -431C>T polymorphism of thymus and activation-regulated chemokine increases the promoter activity but is not associated with susceptibility to atopic dermatitis in Japanese patients.
Experimental dermatology - 1 Nov 2004
Tsunemi Yuichiro, Komine Mayumi, Sekiya Takashi, Saeki Hidehisa, Nakamura Koichiro, Hirai Koichi, Kakinuma Takashi, Kagami Shinji, Fujita Hideki, Asano Noriko, Tanida Yuka, Wakugawa Motoshi, Torii Hideshi, Tamaki Kunihiko
Abstract excerpt
BACKGROUND: Thymus and activation-regulated chemokine (TARC) plays an important role in the pathogenesis of atopic dermatitis (AD). We recently detected the single nucleotide polymorphism (SNP) (-431C>T) in the 5'-flanking region of TARC gene. OBJECTIVES: To examine whether the -431C>T SNP of the TARC gene is associated with susceptibility to AD and whether it affects the promoter activity of the TARC gene....
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