Article
The differences in the involvements of loci of promoter region and Ile50Val in interleukin-4 receptor α chain gene between atopic dermatitis and Japanese cedar pollinosis.
Allergology international : official journal of the Japanese Society of Allergology - 1 Mar 2012
Tanaka Takeshi, Hitomi Yoshiaki, Kambayashi Yasuhiro, Hibino Yuri, Fukutomi Yuma, Shibata Aki, Sugimoto Naotoshi, Hatta Kotaro, Eboshida Akira, Konoshita Tadashi, Nakamura Hiroyuki
Abstract excerpt
BACKGROUND: Atopic dermatitis (AD) and Japanese cedar pollinosis (JCP) are common chronically allergic diseases associated with the activation of T-helper 2 cells. Recent studies have shown that polymorphisms in the genes for IL-4 receptor α chain (IL4RA) may contribute to susceptibility of AD and JCP, although the differences in the involvements of loci of IL4RA gene between AD and JCP are unclear. In this...
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