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Article

A functional polymorphism in the TIM-1 gene is associated with asthma in a Chinese Han population.

International archives of allergy and immunology - 1 Jan 2007

Liu Qiji, Shang Linshan, Li Jisheng, Wang Pin, Li Huaichen, Wei Chunhua, Gong Yaoqin

Abstract excerpt

BACKGROUND: TIM-1, a member of the T cell immunoglobulin and mucin domain (TIM) gene family was implicated as an asthma susceptibility gene in previous studies. TIM-1 is selectively expressed on activated CD4+ T cells and its expression is sustained preferentially on T helper type 2 (Th2) cells, which suggests that TIM-1 is associated with T cell differentiation and the development of Th2-biased immune response....

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PMID: 17570927
DOI: 10.1159/000103992

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