Article
Variations in the human Th2-specific chemokine TARC gene.
Immunogenetics - 1 Jan 2003
Sekiya Takashi, Tsunemi Yuichiro, Miyamasu Misato, Ohta Ken, Morita Atsushi, Saeki Hidehisa, Matsushima Kouji, Yoshie Osamu, Tsuchiya Naoyuki, Yamaguchi Masao, Yamamoto Kazuhiko, Tamaki Kunihiko, Hirai Koichi
Abstract excerpt
Th2-specific chemokine thymus and activation-regulated chemokine (TARC)/CC chemokine ligand (CCL)17 is highly implicated in the pathogenesis of Th-2-dominated allergic diseases such as bronchial asthma (BA) and atopic dermatitis (AD). We performed polymorphism screening of the coding and promoter regions of the TARC gene. We found two rare variations in the coding region of exon 3 (2134C>T and 2037G>A) and a...
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