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Article

Constitutively activated FLT3 phosphorylates BAD partially through pim-1.

British journal of haematology - 1 Sept 2006

Kim Kyu-Tae, Levis Mark, Small Donald

Abstract excerpt

Constitutively activating internal tandem duplication (ITD) mutations of the receptor tyrosine kinase FLT3 (Fms-like tyrosine kinase 3) play an important role in leukaemogenesis and their presence is associated with a poor prognosis in acute myeloid leukaemia (AML). Examining the anti- and proapoptotic proteins in constitutively activated FLT3 signalling in BaF3/ITD and MV4-11 cells, we found that the level of...

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Source

Identifiers

PMID: 16869825
DOI: 10.1111/j.1365-2141.2006.06225.x

Genes

FLT3
BAD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Constitutively activated FLT3 phosphorylates BAD partially through pim-1.PMID 16869825Read ↗

Pim-1 is up-regulated by constitutively activated FLT3 and plays a role in FLT3-mediated cell survival.Semantic proximity Read ↗

The FLT3 internal tandem duplication mutation prevents apoptosis in interleukin-3-deprived BaF3 cells due to protein kinase A and ribosomal S6 kinase 1-mediated BAD phosphorylation at serine 112.Semantic proximity Read ↗

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A potential therapeutic target for FLT3-ITD AML: PIM1 kinase.Semantic proximity Read ↗

Pim-1 kinase phosphorylates and stabilizes 130 kDa FLT3 and promotes aberrant STAT5 signaling in acute myeloid leukemia with FLT3 internal tandem duplication.Semantic proximity Read ↗

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BH3-only protein Bim more critical than Puma in tyrosine kinase inhibitor-induced apoptosis of human leukemic cells and transduced hematopoietic progenitors carrying oncogenic FLT3.Semantic proximity Read ↗

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