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Article

Palbociclib treatment of FLT3-ITD+ AML cells uncovers a kinase-dependent transcriptional regulation of FLT3 and PIM1 by CDK6.

Blood - 9 Jun 2016

Uras Iris Z, Walter Gina J, Scheicher Ruth, Bellutti Florian, Prchal-Murphy Michaela, Tigan Anca S, Valent Peter, Heidel Florian H, Kubicek Stefan, Scholl Claudia, Fröhling Stefan, Sexl Veronika

Abstract excerpt

Up to 30% of patients with acute myeloid leukemia have constitutively activating internal tandem duplications (ITDs) of the FLT3 receptor tyrosine kinase. Such mutations are associated with a poor prognosis and a high propensity to relapse after remission. FLT3 inhibitors are being developed as targeted therapy for FLT3-ITD(+) acute myeloid leukemia; however, their use is complicated by rapid development of...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27099147
DOI: 10.1182/blood-2015-11-683581
PMCID: PMC4920675

Genes

FLT3
CDK6
CDK4
PIM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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