Article
UVB-induced apoptosis drives clonal expansion during skin tumor development.
Carcinogenesis - 1 Jan 2005
Zhang Wengeng, Hanks Adrianne N, Boucher Kenneth, Florell Scott R, Allen Sarah M, Alexander April, Brash Douglas E, Grossman Douglas
Abstract excerpt
The mechanism by which a single mutant cell clonally expands is usually assumed to involve an additional mutation in a cell cycle regulatory gene. An alternative mechanism for driving clonal expansion is apoptosis, which might create vacant stem cell compartments that can be repopulated by mutant cells. This model predicts that in a mouse with reduced apoptotic capacity (i) more mutated cells will appear...
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