Article
Dietary immunosuppressants do not enhance UV-induced skin carcinogenesis, and reveal discordance between p53-mutant early clones and carcinomas.
Cancer prevention research (Philadelphia, Pa.) - 1 Feb 2013
Voskamp Pieter, Bodmann Carolien A, Koehl Gudrun E, Rebel Heggert G, Van Olderen Marjolein G E, Gaumann Andreas, El Ghalbzouri Abdoel, Tensen Cornelis P, Bavinck Jan N Bouwes, Willemze Rein, Geissler Edward K, De Gruijl Frank R
Abstract excerpt
Immunosuppressive drugs are thought to cause the dramatically increased risk of carcinomas in sun-exposed skin of organ transplant recipients. These drugs differ in local effects on skin. We investigated whether this local impact is predictive of skin cancer risk and may thus provide guidance on minimizing the risk. Immunosuppressants (azathioprine, cyclosporine, tacrolimus, mycophenolate mofetil, and rapamycin)...
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