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Article

Antigen-specific immunity does not mediate acute regression of UVB-induced p53-mutant clones.

Oncogene - 25 Sept 2003

Remenyik Eva, Wikonkál Norbert M, Zhang Wengeng, Paliwal Vipin, Brash Douglas E

Abstract excerpt

Chronic irradiation of human or murine epidermis with ultraviolet B (UVB) induces clones of p53-mutant keratinocytes. Clones precede and parallel the induction of carcinomas, suggesting that they are an early stage of UVB carcinogenesis. In the absence of UVB, these clones rapidly regress. For UVB-induced murine skin tumors and papillomas, regression is known to involve antigen-specific immunity. To determine...

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Identifiers

PMID: 14508517
DOI: 10.1038/sj.onc.1206657

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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