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Article

Mutant Brca2/p53 mice exhibit altered radiation responses in the developing mammary gland.

Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie - 1 Nov 2005

Houle Christopher D, Peddada Shyamal D, McAllister Kimberly A, Ward Toni, Malphurs Jason, Gersch William D, Davis Barbara J

Abstract excerpt

Appropriate balance between proliferation and apoptosis is critical for mammary gland development and is often altered during tumorigenesis. Carcinogens like radiation induce DNA damage and activate protective responses such as cell cycle arrest and apoptosis. We used mice carrying Brca2(-/-) and/or p53(-/-) mutations to evaluate the individual and combined effects of these genes on cell proliferation and...

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Identifiers

PMID: 16325521
DOI: 10.1016/j.etp.2005.06.001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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