Article
Overexpression of Bcl-2 protects from ultraviolet B-induced apoptosis but promotes hair follicle regression and chemotherapy-induced alopecia.
The American journal of pathology - 1 Apr 2000
Müller-Röver S, Rossiter H, Paus R, Handjiski B, Peters E M, Murphy J E, Mecklenburg L, Kupper T S
Abstract excerpt
Hair follicle (HF) growth and regression is an exquisitely regulated process of cell proliferation followed by massive cell death and is accompanied by cyclical expression of the apoptosis regulatory gene pair, Bcl-2 and Bax. To further investigate the role of Bcl-2 expression in the control of hair growth and keratinocyte apoptosis, we have used transgenic mice that overexpress human Bcl-2 in basal epidermis and...
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