The growth hormone receptor: mechanism of activation and clinical implications.

doi:10.1038/nrendo.2010.123

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Article

The growth hormone receptor: mechanism of activation and clinical implications.

Nature reviews. Endocrinology - 1 Sept 2010

Brooks Andrew J, Waters Michael J

Abstract excerpt

Growth hormone is widely used clinically to promote growth and anabolism and for other purposes. Its actions are mediated via the growth hormone receptor, both directly by tyrosine kinase activation and indirectly by induction of insulin-like growth factor 1 (IGF-1). Insensitivity to growth hormone (Laron syndrome) can result from mutations in the growth hormone receptor and can be treated with IGF-1. This...

Topics

Animals
Hormone Antagonists
Human Growth Hormone
Humans
Janus Kinase 2
Models, Biological
Models, Molecular
Mutation
Phosphorylation
Receptors, Somatotropin

Source

Open in PubMed

Identifiers

PMID: 20664532
DOI: 10.1038/nrendo.2010.123

Genes

JAK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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