Article
Functional dissection of XDppa2/4 structural domains in Xenopus development.
Mechanisms of development - 1 Dec 2009
Siegel Doreen, Schuff Maximilian, Oswald Franz, Cao Ying, Knöchel Walter
Abstract excerpt
The maintenance of pluripotency in mammalian embryonic stem cells depends upon the expression of regulatory genes like Oct3/4 and Sox2. While homologues of these genes are also characterized in non-mammalian vertebrates, like birds, amphibians and fish, existence and function of developmental pluripotency associated genes (Dppa) in lower vertebrates have not yet been reported. Here we describe a Dppa2/4-like...
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