Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Activin receptor inhibition by Smad2 regulates Drosophila wing disc patterning through BMP-response elements.

Development (Cambridge, England) - 1 Feb 2013

Peterson Aidan J, O'Connor Michael B

Abstract excerpt

Imaginal disc development in Drosophila requires coordinated cellular proliferation and tissue patterning. In our studies of TGFβ superfamily signaling components, we found that a protein null mutation of Smad2, the only Activin subfamily R-Smad in the fruit fly, produces overgrown wing discs that resemble gain of function for BMP subfamily signaling. The wing discs are expanded specifically along the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bone Morphogenetic Proteins
Share to Cell Size
Share to Extracellular Matrix Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Imaginal Discs

Share to Organ Size

Share to Receptors, Transforming Growth Factor beta

Share to Smad2 Protein

Share to Wings, Animal

Source

Open in PubMed Open full text

Identifiers

PMID: 23293296
DOI: 10.1242/dev.085605
PMCID: PMC3561785

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Activin receptor inhibition by Smad2 regulates Drosophila wing disc patterning through BMP-response elements.PMID 23293296Read ↗

Activation and function of TGFβ signalling during Drosophila wing development and its interactions with the BMP pathway.Semantic proximity Read ↗

R-Smad competition controls activin receptor output in Drosophila.Semantic proximity Read ↗

Negative regulation of Smad2 by PIASy is required for proper Xenopus mesoderm formation.Semantic proximity Read ↗

Two highly related regulatory subunits of PP2A exert opposite effects on TGF-beta/Activin/Nodal signalling.Semantic proximity Read ↗

Biochemical Principles of SMAD Signaling Across the Animal KingdomSemantic proximity Read ↗

Smad2 signaling in extraembryonic tissues determines anterior-posterior polarity of the early mouse embryo.Semantic proximity Read ↗

The smad5 mutation somitabun blocks Bmp2b signaling during early dorsoventral patterning of the zebrafish embryo.Semantic proximity Read ↗

Identification of Smad2, a Human Mad-related Protein in the Transforming Growth Factor β Signaling PathwaySemantic proximity Read ↗

Transgenic analysis of the Smad family of TGF-beta signal transducers in Drosophila melanogaster suggests new roles and new interactions between family members.Semantic proximity Read ↗

Smad7-deficient mice show growth retardation with reduced viability.Semantic proximity Read ↗

Dominant-negative Smad2 mutants inhibit activin/Vg1 signaling and disrupt axis formation in Xenopus.Semantic proximity Read ↗

MADR1, a MAD-related protein that functions in BMP2 signaling pathways.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.