Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Modulation of transcription affects mRNP quality.

Molecular cell - 22 Oct 2004

Jensen Torben Heick, Boulay Jocelyne, Olesen Jens Raabjerg, Colin Jessie, Weyler Michael, Libri Domenico

Abstract excerpt

Cotranscriptional loading of proteins onto nascent transcripts contributes to the formation of messenger ribonucleoprotein particles (mRNPs) competent for nuclear export. The transcription machinery is believed to play a pivotal role in mRNP assembly, which is at least partially linked to the function of the THO/TREX complex and the mRNA termination/polyadenylation apparatus. Here we demonstrate a prominent role...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA Helicases
Share to RNA, Messenger
Share to Gene Expression Regulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Ribonucleoproteins

Share to Adenosine Triphosphatases

Share to Saccharomyces cerevisiae Proteins

Share to Transcription, Genetic

Share to Yeasts

Source

Identifiers

PMID: 15494310
DOI: 10.1016/j.molcel.2004.09.019

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Modulation of transcription affects mRNP quality.PMID 15494310Read ↗

Molecular evidence that the eukaryotic THO/TREX complex is required for efficient transcription elongation.Semantic proximity Read ↗

Replication fork progression is impaired by transcription in hyperrecombinant yeast cells lacking a functional THO complex.Semantic proximity Read ↗

Human hHpr1/p84/Thoc1 regulates transcriptional elongation and physically links RNA polymerase II and RNA processing factors.Semantic proximity Read ↗

Dissecting mechanisms of nuclear mRNA surveillance in THO/sub2 complex mutants.Semantic proximity Read ↗

Distinction and relationship between elongation rate and processivity of RNA polymerase II in vivo.Semantic proximity Read ↗

Cotranscriptionally formed DNA:RNA hybrids mediate transcription elongation impairment and transcription-associated recombination.Semantic proximity Read ↗

Participation of XPB/Ptr8p, a component of TFIIH, in nucleocytoplasmic transport of mRNA in fission yeast.Semantic proximity Read ↗

Nuclear mRNA surveillance in THO/sub2 mutants is triggered by inefficient polyadenylation.Semantic proximity Read ↗

THO/Sub2p functions to coordinate 3'-end processing with gene-nuclear pore association.Semantic proximity Read ↗

A reduction in RNA polymerase II initiation rate suppresses hyper-recombination and transcription-elongation impairment of THO mutants.Semantic proximity Read ↗

Different physiological relevance of yeast THO/TREX subunits in gene expression and genome integrity.Semantic proximity Read ↗

Insights into mRNP biogenesis provided by new genetic interactions among export and transcription factors.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.