Article
Methylation patterns and K-ras mutations in tumor and paired serum of resected non-small-cell lung cancer patients.
Cancer letters - 25 Apr 2003
Ramirez Jose Luis, Sarries Carme, de Castro Pedro Lopez, Roig Barbara, Queralt Cristina, Escuin Daniel, de Aguirre Itziar, Sanchez Jose Miguel, Manzano Jose Luis, Margelí Mireia, Sanchez Jose Javier, Astudillo Julio, Taron Miquel, Rosell Rafael
Abstract excerpt
Gene methylation and K-ras mutations were examined in tumor and paired serum DNA of 50 resected non-small-cell lung cancer patients. RASSF1A, death associated protein kinase and target of methylation-induced silencing were methylated in 17/50 (34%), 23/50 (45%) and 18/50 (35%) tumors, respectively, and in 17/50 (34%), 20/50 (40%) and 17/50 (34%) sera, respectively. Methylation in tumor and serum were closely...
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