Article
[Methylation of the promoter region of the RASSF1A gene, a candidate tumor suppressor, in primary epithelial tumors].
Molekuliarnaia biologiia - 1 Jan 2000
Loginov V I, Maliukova A V, Seregin Iu A, Khodyrev D S, Kazubskaia T P, Ermilova V D, Gar'kavtseva R F, Kiselev L L, Zabarovskiĭ E R, Braga E A
Abstract excerpt
Methylation of the promoter CpG-islands of the candidate tumor suppressor gene RASSF1A (3p21.31) was studied in primary tumors of kidney, breast and ovary (172 cases). Methylation-specific PCR (MSP) and methyl-sensitive restriction endonuclease digestion followed by PCR (MSRA) were applied. Statistically significant correlation (P << 10(-6)) was shown for the results of the MSP and MSRA, and the data of bisulfite...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.