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Article

Epigenetic inactivation of the RAS-effector gene RASSF2 in lung cancers.

International journal of oncology - 1 Jul 2007

Kaira Kyoichi, Sunaga Noriaki, Tomizawa Yoshio, Yanagitani Noriko, Ishizuka Tamotsu, Saito Ryusei, Nakajima Takashi, Mori Masatomo

Abstract excerpt

RASSF2, a member of the RAS association domain family 1 (RASSF1), is a candidate tumor suppressor gene (TSG) that is silenced by promoter hypermethylation in several human cancers. In this study, we examined the expression of RASSF2 mRNA and the promoter methylation status in lung cancer cell lines and in tumor samples of 106 primary non-small cell lung cancers (NSCLCs) by methylation-specific PCR. RASSF2...

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Share to Carcinoma, Non-Small-Cell Lung
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Genes, ras

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Share to Proto-Oncogene Proteins p21(ras)

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Source

Identifiers

PMID: 17549418

Genes

RASSF2
EGFR
KRAS
RASSF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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