Myeloperoxidase genotypes and enhanced efficacy of chemotherapy for early-stage breast cancer in SWOG-8897.

doi:10.1200/JCO.2009.21.8669

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Article

Myeloperoxidase genotypes and enhanced efficacy of chemotherapy for early-stage breast cancer in SWOG-8897.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 20 Oct 2009

Ambrosone Christine B, Barlow William E, Reynolds Wanda, Livingston Robert B, Yeh I-Tien, Choi Ji-Yeob, Davis Warren, Rae James M, Tang Li, Hutchins Laura R, Ravdin Peter M, Martino Silvana, Osborne C Kent, Lyss Alan P, Hayes Daniel F, Albain Kathy S

Abstract excerpt

PURPOSE: Myeloperoxidase (MPO) generates reactive oxygen species and also activates xenobiotics. In a rigorous clinical trial (Southwest Oncology Group SWOG-8897), we examined relationships between genotypes and disease-free survival (DFS) among women treated for breast cancer, as well as those who did not receive adjuvant chemotherapy. PATIENTS AND METHODS: Patients were assigned to risk groups according to...

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PMID: 19752340
DOI: 10.1200/JCO.2009.21.8669
PMCID: PMC2799053

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