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Article

Selective Activation of Insulin Receptor Substrate-1 and -2 in Pleural Mesothelioma Cells

15 Oct 2004

Abstract excerpt

Molecular mechanisms active in transforming human pleural cells remain incompletely understood. Our previous microarray analysis of malignant pleural mesothelioma revealed alterations in components of the insulin-like growth factor (IGF) system, implicating this signaling axis in tumorigenesis. Therefore, in this current study, we characterized the molecular phenotype and investigated the key signaling pathways...

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PMID: 15492273
DOI: 10.1158/0008-5472.can-04-1898

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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