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Article

Expression and function of the insulin receptor substrate proteins in cancer

17 Jun 2009

Abstract excerpt

The Insulin Receptor Substrate (IRS) proteins are cytoplasmic adaptor proteins that function as essential signaling intermediates downstream of activated cell surface receptors, many of which have been implicated in cancer. The IRS proteins do not contain any intrinsic kinase activity, but rather serve as scaffolds to organize signaling complexes and initiate intracellular signaling pathways. As common...

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Share to Growth Hormone and Insulin-like Growth Factors
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PMID: 19534786
DOI: 10.1186/1478-811x-7-14

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