Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Interaction of Brn3a and HIPK2 mediates transcriptional repression of sensory neuron survival.

The Journal of cell biology - 25 Oct 2004

Wiggins Amanda K, Wei Guangwei, Doxakis Epaminondas, Wong Connie, Tang Amy A, Zang Keling, Luo Esther J, Neve Rachael L, Reichardt Louis F, Huang Eric J

Abstract excerpt

The Pit1-Oct1-Unc86 domain (POU domain) transcription factor Brn3a controls sensory neuron survival by regulating the expression of Trk receptors and members of the Bcl-2 family. Loss of Brn3a leads to a dramatic increase in apoptosis and severe loss of neurons in sensory ganglia. Although recent evidence suggests that Brn3a-mediated transcription can be modified by additional cofactors, the exact mechanisms are...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to bcl-X Protein
Share to Gene Targeting

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Immunoprecipitation

Share to In Situ Hybridization

Share to Luciferases

Share to Proto-Oncogene Proteins c-bcl-2

Share to Receptor, trkA

Share to Two-Hybrid System Techniques

Source

Open in PubMed Open full text

Identifiers

PMID: 15492043
DOI: 10.1083/jcb.200406131
PMCID: PMC2172556

Genes

HIPK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Interaction of Brn3a and HIPK2 mediates transcriptional repression of sensory neuron survival.PMID 15492043Read ↗

Brn3a and Islet1 act epistatically to regulate the gene expression program of sensory differentiation.Semantic proximity Read ↗

Brn-3a Transcription Factor Blocks p53-mediated Activation of Proapoptotic Target Genes Noxa and Bax in Vitro and in Vivo to Determine Cell FateSemantic proximity Read ↗

The evolutionarily conserved transcription factor PRDM12 controls sensory neuron development and pain perception.Semantic proximity Read ↗

Prdm12 Directs Nociceptive Sensory Neuron Development by Regulating the Expression of the NGF Receptor TrkASemantic proximity Read ↗

FOXO transcription factors directly activate <i>bim</i> gene expression and promote apoptosis in sympathetic neuronsSemantic proximity Read ↗

Pin1 promotes cell death in NGF-dependent neurons through a mechanism requiring c-Jun activity.Semantic proximity Read ↗

Bim Is a Direct Target of a Neuronal E2F-Dependent Apoptotic PathwaySemantic proximity Read ↗

Human PRKC apoptosis WT1 regulator is a novel PITX2-interacting protein that regulates PITX2 transcriptional activity in ocular cells.Semantic proximity Read ↗

The Semaphorin receptor PlexinA3 mediates neuronal apoptosis during dorsal root ganglia development.Semantic proximity Read ↗

Regulation of BNIP3 in Normal and Cancer CellsSemantic proximity Read ↗

Dlx2 homeobox gene transcriptional regulation of Trkb neurotrophin receptor expression during mouse retinal development.Semantic proximity Read ↗

Pro-apoptotic Bim induction in response to nerve growth factor deprivation requires simultaneous activation of three different death signaling pathways.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.