Article
The Semaphorin receptor PlexinA3 mediates neuronal apoptosis during dorsal root ganglia development.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 19 Nov 2008
Ben-Zvi Ayal, Manor Osnat, Schachner Melitta, Yaron Avraham, Tessier-Lavigne Marc, Behar Oded
Abstract excerpt
Extensive neuronal cell death during development is believed to be due to a limiting supply of neurotrophic factors. In vitro studies suggest that axon guidance molecules directly regulate neuronal survival, raising the possibility that they play a direct role in neuronal cell death in vivo. However, guidance errors may also influence survival indirectly due to loss of target-derived neurotrophic support. The...
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