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Article

The evolutionarily conserved transcription factor PRDM12 controls sensory neuron development and pain perception.

Cell cycle (Georgetown, Tex.) - 1 Jan 2015

Nagy Vanja, Cole Tiffany, Van Campenhout Claude, Khoung Thang M, Leung Calvin, Vermeiren Simon, Novatchkova Maria, Wenzel Daniel, Cikes Domagoj, Polyansky Anton A, Kozieradzki Ivona, Meixner Arabella, Bellefroid Eric J, Neely G Gregory, Penninger Josef M

Abstract excerpt

PR homology domain-containing member 12 (PRDM12) belongs to a family of conserved transcription factors implicated in cell fate decisions. Here we show that PRDM12 is a key regulator of sensory neuronal specification in Xenopus. Modeling of human PRDM12 mutations that cause hereditary sensory and autonomic neuropathy (HSAN) revealed remarkable conservation of the mutated residues in evolution. Expression of...

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Identifiers

PMID: 25891934
DOI: 10.1080/15384101.2015.1036209
PMCID: PMC4613559

Genes

PRDM12
TRHDE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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