Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Human PRKC apoptosis WT1 regulator is a novel PITX2-interacting protein that regulates PITX2 transcriptional activity in ocular cells.

The Journal of biological chemistry - 11 Dec 2009

Acharya Moulinath, Lingenfelter David J, Huang Lijia, Gage Philip J, Walter Michael A

Abstract excerpt

Mutations in the homeobox transcription factor PITX2 result in Axenfeld-Rieger syndrome (ARS), which is associated with anterior segment dysgenesis and an increased risk of glaucoma. To understand the pathogenesis of the defects resulting from PITX2 mutations, it is essential to know the normal functions of PITX2 and its interaction with the network of proteins in the eye. Yeast two-hybrid screening was performed...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Apoptosis Regulatory Proteins
Share to Eye

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Eye Proteins

Share to Homeobox Protein PITX2

Share to Homeodomain Proteins

Share to Protein Isoforms

Share to Trabecular Meshwork

Share to Two-Hybrid System Techniques

Source

Open in PubMed Open full text

Identifiers

PMID: 19801652
DOI: 10.1074/jbc.M109.006684
PMCID: PMC2787345

Genes

PITX2
PAWR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Human PRKC apoptosis WT1 regulator is a novel PITX2-interacting protein that regulates PITX2 transcriptional activity in ocular cells.PMID 19801652Read ↗

PITX2 gain-of-function in Rieger syndrome eye model.Semantic proximity Read ↗

PITX2 deficiency and associated human disease: insights from the zebrafish model.Semantic proximity Read ↗

PITX2 Is Involved in Stress Response in Cultured Human Trabecular Meshwork Cells through Regulation of SLC13A3Semantic proximity Read ↗

Identification of a novel frameshift mutation in PITX2 gene in a Chinese family with Axenfeld-Rieger syndrome.Semantic proximity Read ↗

A missense mutation in Pitx2 leads to early-onset glaucoma via NRF2-YAP1 axis.Semantic proximity Read ↗

Identification of four new PITX2 gene mutations in patients with Axenfeld-Rieger syndrome.Semantic proximity Read ↗

Functional interactions between FOXC1 and PITX2 underlie the sensitivity to FOXC1 gene dose in Axenfeld-Rieger syndrome and anterior segment dysgenesis.Semantic proximity Read ↗

A de novo mutation in PITX2 underlies a unique form of Axenfeld-Rieger syndrome with corneal neovascularization and extensive proliferative vitreoretinopathy.Semantic proximity Read ↗

Pituitary homeobox 2, a novel member of the bicoid-related family of homeobox genes, is a potential regulator of anterior structure formation.Semantic proximity Read ↗

Functional analyses of two newly identified PITX2 mutants reveal a novel molecular mechanism for Axenfeld-Rieger syndrome.Semantic proximity Read ↗

Pits and CtBP control tissue growth in <i>Drosophila melanogaster</i> with the Hippo pathway transcription repressor, TgiSemantic proximity Read ↗

A PITX2 splice-site mutation in a family with Axenfeld-Rieger syndrome leads to decreased expression of nuclear PITX2 protein.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.