Article
Dlx2 homeobox gene transcriptional regulation of Trkb neurotrophin receptor expression during mouse retinal development.
Nucleic acids research - 1 Feb 2008
de Melo Jimmy, Zhou Qing-Ping, Zhang Qi, Zhang Shunzhen, Fonseca Mario, Wigle Jeffrey T, Eisenstat David D
Abstract excerpt
Dlx homeobox genes are first expressed in embryonic retina at E11.5. The Dlx1/Dlx2 null retina has a reduced ganglion cell layer (GCL), with loss of late-born differentiated retinal ganglion cells (RGCs) due to increased apoptosis. TrkB signaling is proposed to regulate the dynamics of RGC apoptosis throughout development. DLX2 expression markedly precedes the onset of TrkB expression in the GCL; TrkB...
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