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Article

Cellular context‐dependent “colors” of transforming growth factor‐β signaling

17 Nov 2009

Abstract excerpt

Transforming growth factor (TGF)-beta signaling has interesting characteristics in the context of cancer. Although perturbations of TGF-beta signaling are strongly implicated in cancer progression, TGF-beta signaling has both tumor-suppressive and tumor-promoting effects. For example, TGF-beta inhibits cancer cell proliferation in some cellular contexts, but promotes it in others. Although several approaches to...

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PMID: 20067465
DOI: 10.1111/j.1349-7006.2009.01441.x

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