Article
Human p53 and CDC2Hs genes combine to inhibit the proliferation of Saccharomyces cerevisiae.
Molecular and cellular biology - 1 Mar 1992
Nigro J M, Sikorski R, Reed S I, Vogelstein B
Abstract excerpt
Human wild-type and mutant p53 genes were expressed under the control of a galactose-inducible promoter in Saccharomyces cerevisiae. The growth rate of the yeast was reduced in cells expressing wild-type p53, whereas cells transformed with mutant p53 genes derived from human tumors were less affected. Coexpression of the normal p53 protein with the human cell cycle-regulated protein kinase CDC2Hs resulted in much...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.