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Article

Accumulation of p53 in a mutant cell line defective in the ubiquitin pathway.

Molecular and cellular biology - 1 Mar 1994

Chowdary D R, Dermody J J, Jha K K, Ozer H L

Abstract excerpt

The wild-type p53 gene product plays an important role in the control of cell proliferation, differentiation, and survival. Altered function is frequently associated with changes in p53 stability. We have studied the role of the ubiquitination pathway in the degradation of p53, utilizing a temperature-sensitive mutant, ts20, derived from the mouse cell line BALB/c 3T3. We found that wild-type p53 accumulates...

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Identifiers

PMID: 8114731
DOI: 10.1128/mcb.14.3.1997-2003.1994
PMCID: PMC358559

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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