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Article

Accumulation of p53 in a mutant cell line defective in the ubiquitin pathway.

Molecular and cellular biology - 1 Mar 1994

Chowdary D R, Dermody J J, Jha K K, Ozer H L

Abstract excerpt

The wild-type p53 gene product plays an important role in the control of cell proliferation, differentiation, and survival. Altered function is frequently associated with changes in p53 stability. We have studied the role of the ubiquitination pathway in the degradation of p53, utilizing a temper...

Topics

3T3 Cells
Animals
In Vitro Techniques
Ligases
Mice
Mutation
Tumor Suppressor Protein p53
Ubiquitin-Activating Enzymes
Ubiquitin-Protein Ligases
Ubiquitins

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 8114731
DOI: 10.1128/mcb.14.3.1997-2003.1994
PMCID: PMC358559

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8114731-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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