Article
Distinct roles for the Saccharomyces cerevisiae mismatch repair proteins in heteroduplex rejection, mismatch repair and nonhomologous tail removal.
Genetics - 1 Feb 2005
Goldfarb Tamara, Alani Eric
Abstract excerpt
The Saccharomyces cerevisiae mismatch repair (MMR) protein MSH6 and the SGS1 helicase were recently shown to play similarly important roles in preventing recombination between divergent DNA sequences in a single-strand annealing (SSA) assay. In contrast, MMR factors such as Mlh1p, Pms1p, and Exo1p were shown to not be required or to play only minimal roles. In this study we tested mutations that disrupt Sgs1p...
Topics
- Adenosine Triphosphate
- Base Pair Mismatch
- DNA Helicases
- DNA Repair
- DNA Replication
- DNA, Fungal
- Models, Genetic
- Mutation
- Nucleic Acid Heteroduplexes
- Recombination, Genetic
- Saccharomyces cerevisiae
- Saccharomyces cerevisiae Proteins