Article
Msh2 blocks an alternative mechanism for non-homologous tail removal during single-strand annealing in Saccharomyces cerevisiae.
PloS one - 16 Oct 2009
Manthey Glenn M, Naik Nilan, Bailis Adam M
Abstract excerpt
Chromosomal translocations are frequently observed in cells exposed to agents that cause DNA double-strand breaks (DSBs), such as ionizing radiation and chemotherapeutic drugs, and are often associated with tumors in mammals. Recently, translocation formation in the budding yeast, Saccharomyces cerevisiae, has been found to occur at high frequencies following the creation of multiple DSBs adjacent to repetitive...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
