The DNA damage checkpoint allows recombination between divergent DNA sequences in budding yeast.

doi:10.1016/j.dnarep.2011.07.007

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Article

The DNA damage checkpoint allows recombination between divergent DNA sequences in budding yeast.

DNA repair - 10 Nov 2011

George Carolyn M, Lyndaker Amy M, Alani Eric

Abstract excerpt

In the early steps of homologous recombination, single-stranded DNA (ssDNA) from a broken chromosome invades homologous sequence located in a sister or homolog donor. In genomes that contain numerous repetitive DNA elements or gene paralogs, recombination can potentially occur between non-allelic/divergent (homeologous) sequences that share sequence identity. Such recombination events can lead to lethal...

Topics

Cell Cycle Checkpoints
Cell Cycle Proteins
DNA Damage
DNA Repair
DNA, Fungal
Homologous Recombination
Mutation
Nocodazole
Nucleic Acid Heteroduplexes
Recombination, Genetic
Saccharomycetales

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Identifiers

PMID: 21978436
DOI: 10.1016/j.dnarep.2011.07.007
PMCID: PMC3201711

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