Article
Effects of the loss of mismatch repair genes on single-strand annealing between divergent sequences in Saccharomyces cerevisiae.
Journal of microbiology (Seoul, Korea) - 1 Apr 2021
Lim Ye-Seul, Choi Ju-Hee, Ahn Kyu-Jin, Kim Min-Ku, Bae Sung-Ho
Abstract excerpt
Eukaryotic genomes contain many duplicated genes closely located with each other, such as the hexose transporter (HXT) genes in Saccharomyces cerevisiae. They can potentially recombine via single-strand annealing (SSA) pathway. SSA between highly divergent sequences generates heteroduplex DNA intermediates with many mismatches, which can be corrected by mismatch repair (MMR), resulting in recombinant sequences...
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