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Rad27 and Exo1 function in different excision pathways for mismatch repair in Saccharomyces cerevisiae.

Nature communications - 22 Sept 2021

Calil Felipe A, Li Bin-Zhong, Torres Kendall A, Nguyen Katarina, Bowen Nikki, Putnam Christopher D, Kolodner Richard D

Abstract excerpt

Eukaryotic DNA Mismatch Repair (MMR) involves redundant exonuclease 1 (Exo1)-dependent and Exo1-independent pathways, of which the Exo1-independent pathway(s) is not well understood. The exo1Δ440-702 mutation, which deletes the MutS Homolog 2 (Msh2) and MutL Homolog 1 (Mlh1) interacting peptides (SHIP and MIP boxes, respectively), eliminates the Exo1 MMR functions but is not lethal in combination with rad27Δ...

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DNA, Fungal
DNA Ligases
DNA Mismatch Repair
Exodeoxyribonucleases
Flap Endonucleases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Proliferating Cell Nuclear Antigen

Saccharomyces cerevisiae Proteins

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Identifiers

PMID: 34552065
DOI: 10.1038/s41467-021-25866-z
PMCID: PMC8458276

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