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Article

Heteroduplex rejection during single-strand annealing requires Sgs1 helicase and mismatch repair proteins Msh2 and Msh6 but not Pms1.

Proceedings of the National Academy of Sciences of the United States of America - 22 Jun 2004

Sugawara Neal, Goldfarb Tamara, Studamire Barbara, Alani Eric, Haber James E

Abstract excerpt

Recombination between moderately divergent DNA sequences is impaired compared with identical sequences. In yeast, an HO endonuclease-induced double-strand break can be repaired by single-strand annealing (SSA) between flanking homologous sequences. A 3% sequence divergence between 205-bp sequences flanking the double-strand break caused a 6-fold reduction in repair compared with identical sequences. This...

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Source

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Identifiers

PMID: 15199178
DOI: 10.1073/pnas.0305749101
PMCID: PMC438974

Genes

PMS1
MLH1
MLH3
MSH2
MSH6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Heteroduplex rejection during single-strand annealing requires Sgs1 helicase and mismatch repair proteins Msh2 and Msh6 but not Pms1.PMID 15199178Read ↗

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