Article
Helicobacter pylori lipopolysaccharide is synthesized via a novel pathway with an evolutionary connection to protein N-glycosylation.
PLoS pathogens - 19 Mar 2010
Hug Isabelle, Couturier Marc R, Rooker Michelle M, Taylor Diane E, Stein Markus, Feldman Mario F
Abstract excerpt
Lipopolysaccharide (LPS) is a major component on the surface of Gram negative bacteria and is composed of lipid A-core and the O antigen polysaccharide. O polysaccharides of the gastric pathogen Helicobacter pylori contain Lewis antigens, mimicking glycan structures produced by human cells. The i...
Topics
- Cell Line
- Epithelial Cells
- Escherichia coli
- Escherichia coli Proteins
- Evolution, Molecular
- Gastric Mucosa
- Glycosylation
- Glycosyltransferases
- Helicobacter pylori
- Humans
- Lewis Blood Group Antigens
- Ligases
- Lipopolysaccharides
- Mutation
- O Antigens