Article
Helicobacter pylori lipopolysaccharide is synthesized via a novel pathway with an evolutionary connection to protein N-glycosylation.
PLoS pathogens - 19 Mar 2010
Hug Isabelle, Couturier Marc R, Rooker Michelle M, Taylor Diane E, Stein Markus, Feldman Mario F
Abstract excerpt
Lipopolysaccharide (LPS) is a major component on the surface of Gram negative bacteria and is composed of lipid A-core and the O antigen polysaccharide. O polysaccharides of the gastric pathogen Helicobacter pylori contain Lewis antigens, mimicking glycan structures produced by human cells. The interaction of Lewis antigens with human dendritic cells induces a modulation of the immune response, contributing to...
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